Expectant women who increase their intake of omega-3 long-chain polyunsaturated fatty acids (LCPUFA) can reduce the risk of premature birth, according to a new study published in the Cochrane Review.
“We know premature birth is a critical global health issue, with an estimated 15 million babies born too early each year,” said Associate Professor Philippa Middleton from Cochrane Pregnancy and Childbirth and the South Australian Health and Medical Research Institute (SAHMRI).
“While the length of most pregnancies is between 38 and 42 weeks, premature babies are those born before the 37-week mark — and the earlier a baby is born, the greater the risk of death or poor health.”
Infants born prematurely are at greater risk of a range of long-term conditions including visual impairment, developmental delay and learning difficulties.
Middleton and a team of Cochrane researchers have been looking closely at long-chain omega-3 fats and their role in reducing the risk of premature births; particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) found in fatty fish and fish oil supplements.
For the study, they reviewed 70 randomized trials and found that for pregnant women, increasing the daily intake of long-chain omega-3s:
- lowers the risk of having a premature baby (less than 37 weeks) by 11 percent (from 134 per 1,000 to 119 per 1,000 births);
- reduces the risk of having an early premature baby (less than 34 weeks) by 42 percent (from 46 per 1,000 to 27 per 1,000 births);
- lowers the risk of having a small baby (less than 5.5 pounds or 2,500g) by 10 percent.
“There are not many options for preventing premature birth, so these new findings are very important for pregnant women, babies and the health professionals who care for them,” Middleton says.
“We don’t yet fully understand the causes of premature labor, so predicting and preventing early birth has always been a challenge. This is one of the reasons omega-3 supplementation in pregnancy is of such great interest to researchers around the world.”
This review was first undertaken back in 2006. At that time, the researchers had concluded there wasn’t enough evidence to support the routine use of omega-3 fatty acid supplements during pregnancy. Over a decade later, however, this updated review concludes that there’s high quality evidence for omega-3 supplementation to be used as an effective strategy for preventing preterm birth.
“Many pregnant women in the UK are already taking omega-3 supplements by personal choice rather than as a result of advice from health professionals,” Middleton said.
“It’s worth noting though that many supplements currently on the market don’t contain the optimal dose or type of omega-3 for preventing premature birth. Our review found the optimum dose was a daily supplement containing between 500 and 1000 milligrams (mg) of long-chain omega-3 fats (containing at least 500mg of DHA) starting at 12 weeks of pregnancy.
“Ultimately, we hope this review will make a real contribution to the evidence base we need to reduce premature births, which continue to be one of the most pressing and intractable maternal and child health problems in every country around the world.”